pH-Sensitive self-assembling nanoparticles for tumor near-infrared fluorescence imaging and chemo–photodynamic combination therapy
نویسندگان
چکیده
منابع مشابه
Near-Infrared Fluorescence Optical Imaging and Tomography
The advent of recent advances in near-infrared laser diodes and fast electro-optic detection has spawned a new research field of diagnostic spectroscopy and imaging based on targeting and reporting exogenous fluorescent agents. This review seeks to concisely address the physics, instrumentation, advancements in tomography, and near-infrared fluorescent contrast agent development that promises s...
متن کاملBiodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging.
The overproduction of acidic byproducts is implicated in the development of numerous diseases, and there is currently great interest in developing contrast agents that can image acidic tissue in vivo.1 Here we report a pH-sensing biodegradable near-infrared (NIR) nanoprobe capable of providing complementary information through both fluorescence lifetime measurements and signal amplification in ...
متن کاملSmart pH-responsive upconversion nanoparticles for enhanced tumor cellular internalization and near-infrared light-triggered photodynamic therapy.
A smart pH-responsive photodynamic therapy system based on upconversion nanoparticle loaded PEG coated polymeric lipid vesicles (RB-UPPLVs) was designed and prepared. These RB-UPPLVs which are promising agents for deep cancer photodynamic therapy applications can achieve enhanced tumor cellular internalization and near-infrared light-triggered photodynamic therapy.
متن کاملA coumarin-indole-based near-infrared ratiometric pH probe for intracellular fluorescence imaging.
New pH-activatable ratiometric fluorescent probes have been developed that have a coumarin structure attached to benzothiazole or indole units with one or two conjugated bonds. They have optical responses in acidic conditions. Probes with benzothiazole (1) and indole (2, 3) units have opposite responses to changes in pH, in terms of shifts in absorption and emission. Quantum chemical calculatio...
متن کاملSelective imaging and cancer cell death via pH switchable near-infrared fluorescence and photothermal effects
Key Laboratory of Smart Drug Delivery, Mi Fudan University, Shanghai 201203, China. State Key Laboratory of Oncogenes and Re School of Biomedical Engineering, Shangh Road, Shanghai, 200030, China. E-mail: xw Department of Chemistry, National Univ Singapore Department of Neurosurgery, Huashan Hosp China † Electronic supplementary informa characterization, experimental details an 10.1039/c6sc0022...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanoscale
سال: 2016
ISSN: 2040-3364,2040-3372
DOI: 10.1039/c5nr06842h